immune response to standard hepatitis b vaccination in hiv-infected patients
نویسندگان
چکیده
background: due to their similar routes of transmission, human immunodeficiency virus (hiv) and hepatitis b virus (hbv) co-infection occurs considerably. hbv infection progresses more rapidly in hiv-infected patients. therefore, hbv vaccination of all non-immune hiv infected patients is recommended. on the other hand, hiv-infected subjects have suboptimal responses to hbv vaccine. in this study, we aimed to determine the immune responses to standard hbv vaccination in hiv-infected patients. methods: fifty-six hiv infected patients who lacked evidence of either prior hbv infection or immunity were subjected to standard hbv vaccination, as 3 intramuscular injections of the standard dose (20 μg) of recombinant hbv vaccine at months 0, 1 and 6. hepatitis b surface antibody (anti-hbs) titers were checked in all cases one month after the vaccination. a protective antibody response was defined as an anti-hbs titer of ≥10 iu/l. results: hbv seroprotection was observed in 56.6% of hiv-infected patients. there was no significant difference between cases with and without seroprotection regarding age, sex, possible route of hiv acquisition, cd4 count, receiving antiretroviral therapy (and its duration) and hcv infection. conclusion: our study confirms previous reports that hiv-infected patients have a lower response rate to the standard hbv vaccination compared to general population. so other strategies are needed to improve the hbv vaccine response rate in hiv cases.
منابع مشابه
Immune Response to Standard Hepatitis B Vaccination in HIV-Infected Patients
Background: Due to their similar routes of transmission, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) co-infection occurs considerably. HBV infection progresses more rapidly in HIV-infected patients. Therefore, HBV vaccination of all non-immune HIV infected patients is recommended. On the other hand, HIV-infected subjects have suboptimal responses to HBV vaccine. In this study...
متن کاملcan Isolated hepatitis B core antibody in HIV-infected patients response to hepatitis B vaccine help to elucidate the cause?
متن کامل
Factors for predicting successful immune response to hepatitis B vaccination in HIV-1 infected patients.
This study aimed to determine the predicting factors for successful hepatitis B vaccination among HIV-1 infected patients. A prospective study was conducted among HIV-1 infected patients who had negative HBV serologies. Anti-HBs antibody was evaluated one month after completing a 3-injection course of hepatitis B vaccine. Patients who had an anti-HBs antibody level >10 mlU/ml were defined as re...
متن کاملImmune response to hepatitis B virus vaccination among HIV-1 infected and uninfected adults in Kenya.
BACKGROUND In studies from high-income countries, human immunodeficiency virus type 1 (HIV-1)-infected persons have diminished responses to hepatitis B virus (HBV) vaccination, compared with HIV-1-uninfected persons, but data from other settings are limited. METHODS We compared the immune response to HBV vaccination among HIV-1-infected and HIV-1-uninfected Kenyan adults and assessed the resp...
متن کاملAn Investigation of the Immune Response to Hepatitis B Vaccination in Hemodialysis Patients at Dialysis Centers of Tehran (2016)
Background: Hemodialysis (HD) patients are at an increased risk of acquiring the hepatitis B (HB) virus and having lower protective antibody levels as well as shorter durations of seroprotection. This study aims to determine the immune response of HB vaccination in HD patients referring to dialysis centers of the Tehran North Health Network. Materials and Methods: This descriptive study was co...
متن کاملSerologic response to hepatitis B vaccination in HIV-Infected patients with isolated positivity for antibodies to hepatitis B core antigen.
We assessed the safety and immunogenicity of hepatitis B vaccination among 40 human immunodeficiency virus-infected patients with isolated positivity for antibodies to hepatitis B core antigen. No baseline factors were found to be predictive of an anamnestic response, which occurred in 32.5% of the patients. The overall response rate among patients without an anamnestic response was 74.0% after...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
vaccine researchجلد ۱، شماره ۲، صفحات ۱۲-۱۵
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023